In my opinion (although I don't manage any users, so my advice might be off-base), I would set up schedules for the logical divisions in resources. Those divisions are your call, of course, but I would put all conference rooms on a Conference Room schedule, all equipment on it's own schedule and so on.
It's either that or use location. We have multiple buildings, I was thinking a schedule for each building, then add the resources.
Permissions becomes tricky. If there are resources that don't need restrictive permissions, just turn on auto-assign for them and hand-tune permissions on other resources. Otherwise you will probably have to take the upfront hit of setting all permissions, then just minor tweaks as new users are added. The upcoming 1.2 release has support for groups, where a group admin can handle management of permissions.
Hopefully that's some help for you. Good luck.
The 1.2 release sounds ideal - The reason I'm struggling with permissions is that there is no consensus among the users about how they should work, and different groups of users have different needs.
Is there an anticipated timeframe for the 1.2 release?
For those of you that support a larger user base, how have you added/managed users?